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One-pot, three-component, sequential Michael-Michael-ring-closure reactions. Annulation of meta-dicarboxylated aromatic rings. Total synthesis of juncunol

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Abstract

The preparative value of one-pot, multicomponent, sequential Michael-Michael-ring-closure reactions followed by aromatization is illustrated in two ways: (1) by a multi-gram example, and (2) by a total synthesis of juncunol, an unusual vinyldihydrophenanthrene.

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Authors and Affiliations

  1. Department of Chemistry, The Johns Hopkins University, 21218, Baltimore, Maryland, USA

    Gary H. Posner, Karen A. Canella & Ernest F. Silversmith

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  1. Gary H. Posner
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  2. Karen A. Canella
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  3. Ernest F. Silversmith
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Posner, G.H., Canella, K.A. & Silversmith, E.F. One-pot, three-component, sequential Michael-Michael-ring-closure reactions. Annulation of meta-dicarboxylated aromatic rings. Total synthesis of juncunol. Proc. Indian Acad. Sci. (Chem. Sci.) 100, 81–90 (1988). https://doi.org/10.1007/BF02839442

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