Summary
The infusion of Histalog can produce constant maximal stimulation of the gastric acid and volume, without adverse effects. This technique would seem to be an excellent tool for human gastric experimentation. It has been especially useful in our laboratory in the evaluation of gastric inhibitory agents.
Similar content being viewed by others
References
Bockus, H. L., andBank, J. Value of histamine as a test of gastric function.Arch Int Med 39:508, 1927.
Weiss, S., Robb, G. P., andEllis, J. B. Systemic effects of histamine in man, with special reference to responses of cardiovascular system.Arch Int Med 49: 360, 1932.
Kay, A. W. Effect of large doses of histamine on gastric secretion of HCl.Brit Med J 2:77, 1953.
Rosiere, C. E., andGrossman, M. I. An analog of histamine that stimulates gastric acid secretion without other actions of histamine.Science 113:651, 1951.
Ward, S., Gillespie, I. E., Passaro, E. P., andGrossman, M. I. Comparison of Histalog and histamine as stimulants for maximal gastric secretion in human subjects and in dogs.Gastroenterology 44:620, 1963.
Adam, H. M., Card, W. I., Riddell, M. J., Roberts, M., Strong, J. A., andWolf, B. Dose-response curves for the effect of histamine on acid gastric secretion in man.Brit J Pharm 9:329, 1954.
Lawrie, J. H., Smith, G. M. R., andForrest, A. P. M. The histamine-infusion test.Lancet 2:270, 1964.
Author information
Authors and Affiliations
Additional information
Supported in part by a Memphis Heart Association grant.
Rights and permissions
About this article
Cite this article
Wruble, L.D., Cummins, A.J., Goldenberg, J. et al. The effect of intravenous histalog on gastric secretion in man. Digest Dis Sci 12, 1087–1090 (1967). https://doi.org/10.1007/BF02233873
Issue Date:
DOI: https://doi.org/10.1007/BF02233873