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Assignment to chromosome 16 of a gene necessary for the expression of human mitochondrial glutamate oxaloacetate transaminase (aspartate aminotransferase) (E.C. 2.6.1.1.)

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Abstract

A gene necessary for the expression of human mitochondrial glutamate oxaloacetate transaminase (GOT-2) has been assigned to chromosome 16 on the basis of an immunochemical analysis of human-mouse somatic cell hybrids. Mitochondrial GOT cosegregates with adenine phosphoribosyl transferase (E.C. 2.4.2.7.).

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References

  • Barra, D., Bossa, F., Doonan, S., Fahmy, H. M. A., Hughes, G. J., Kakoz, K. Y., Martini, F., and Petruzzelli, R. (1977). The structure of mitochondrial aspartate aminotransferase from pigheart and comparison with that of the cytoplasmic isozyme. FEBS Lett. 83241.

    Google Scholar 

  • Bobrow, M., and Cross, J. (1975). Differential staining of human and mouse chromosomes in interspecific cell hybrids. Nature 25177.

    Google Scholar 

  • Caspersson, T., Zech, L., Harris, H. Wiener, F., and Klein, G. (1971). Identification of human chromosomes in a mouse/human hybrid by fluorescence techniques. Exp. Cell Res. 65475.

    Google Scholar 

  • Creagan, R., Tischfield, J., McMorris, F. A., Chen, S., Hirschi, M., Chen, T. R., Ricciuti, F., and Ruddle, F. H. (1973). Assignment of the genes for human peptidase A to chromosome 18 and cytoplasmic glutamate oxaloacetate transmainase to chromosome 10 using somatic cell hybrids. Cytogenet. Cell Genet. 12187.

    Google Scholar 

  • Craig, I. W., Tolley, E., Bobrow, M., and van Heyningen, V. (1977). Assignment of a gene necessary for the expression of mitochondrial glutamic-oxaloacetic transaminase in human-mouse hybrid cells. Fourth International Workshop on Human Gene Mapping. Birth Defects Orig. Art. Ser 14190.

    Google Scholar 

  • Edwards, Y. H., and Hopkinson, D. A. (1979). The genetic determination of fumarase isozymes in human tissues. Ann. Hum. Genet. 42303.

    Google Scholar 

  • Jones, E. A., Goodfellow, P. N., Kennett, R. H., and Bodmer, W. F. (1976). The independent expression of HLA and β2-microglobin on human-mouse hybrids. Somat. Cell Genet. 2483.

    Google Scholar 

  • Kagamiyama, H., Sakakibara, R., Wada, H., Tanasa, S., and Morino, Y. (1977). The complete amino acid sequences of mitochondrial aspartate aminotransferase from pig heart. J. Biochem. 82291.

    Google Scholar 

  • Lalley, P. A., Francke, U., and Minna, J. D. (1978). Comparative gene mapping; The linkage relationships of the homologous genes for phosphoglucomutase and peptidase S are conserved in man and mouse. Cytogenet. Cell Genet. 22570.

    Google Scholar 

  • Nabholz, M. (1969). D.Phil. thesis, Stanford University.

  • Nabholz, M., Miggiano, V., and Bodmer, W. (1969). Genetic analysis with human-mouse somatic cell hybrids. Nature 222358.

    Google Scholar 

  • Orkwiszewski, K. G., Tadesco, T. A., and Croce, C. M. (1974). Assignment of the human gene for galactokinase to chromosome 17. Nature 25260.

    Google Scholar 

  • Ruddle, F. H. (1973). Linkage analysis in man by somatic cell genetics. Nature 242165.

    Google Scholar 

  • Santachiara, A. S., Nabholz, M., Miggiano, V., Darlington, A. J., and Bodmer, W. (1970). Genetic analysis with man-mouse somatic cell hybrids. Nature 227248.

    Google Scholar 

  • Solomon, E., Bobrow, M., Goodfellow, P. N., Bodmer, W. F., Swallow, D. M., Povey, S., and Noël, B. (1976). Human gene mapping using an X/autosome translocation. Som. Cell Genet. 2125.

    Google Scholar 

  • Sonderegger, P., and Christen, P. (1978). Comparison of the evolution rates of cytosolic and mitochondrial aspartate aminotransferase. Nature 275157.

    Google Scholar 

  • Teranishi, H., Kagamiyama, H., Teranishi, D., Wada, H., Yamano, T., and Morino, Y. (1978). Cytosolic and mitochondrial isoenzymes of glutamic oxalacetic transaminase from human heart: Structural comparison with the isoenzymes from pigheart. J. Biol. Chem. 2538842.

    Google Scholar 

  • Tischfield, J. A., and Ruddle, F. (1974). Assignment of the gene for adenine phosphoribosyl-transferase to human chromosome 16 by mouse-human somatic cell hybridization. Proc. Natl. Acad. Sci. 7145.

    Google Scholar 

  • Tolley, E. (1977). M.Sc. thesis, Oxford University.

  • Tolley, E., and Craig, I., (1975). Presence of two forms of fumarase (fumarate hydratase E.C. 4.2.1.2.) in mammalian cells: Immunological characterization and genetic analysis in somatic cell hybrids. Confirmation of the assignment of a gene necessary for the enzyme expression to human chromosome 1. Biochem. Genet. 13867.

    Google Scholar 

  • van Heyningen, V. (1973). D.Phil. thesis, Oxford University.

  • van Heyningen, V., Craig, I. W., and Bodmer, W. F. (1973). Genetic control of mitochondrial enzymes in human-mouse somatic cell hybrids. Nature 242509.

    Google Scholar 

  • van Heyningen, V., Craig, I. W., and Bodmer, W. F. (1974). Mitochondrial enzymes in man-mouse hybrid cells. In Kroon, A. M., and Saccone, C. (eds.), The Biogenesis of Mitochondria Academic Press, New York, p. 231.

    Google Scholar 

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Tolley, E., van Heyningen, V., Brown, R. et al. Assignment to chromosome 16 of a gene necessary for the expression of human mitochondrial glutamate oxaloacetate transaminase (aspartate aminotransferase) (E.C. 2.6.1.1.). Biochem Genet 18, 947–954 (1980). https://doi.org/10.1007/BF00500127

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  • DOI: https://doi.org/10.1007/BF00500127

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