Abstract
A gene necessary for the expression of human mitochondrial glutamate oxaloacetate transaminase (GOT-2) has been assigned to chromosome 16 on the basis of an immunochemical analysis of human-mouse somatic cell hybrids. Mitochondrial GOT cosegregates with adenine phosphoribosyl transferase (E.C. 2.4.2.7.).
Similar content being viewed by others
References
Barra, D., Bossa, F., Doonan, S., Fahmy, H. M. A., Hughes, G. J., Kakoz, K. Y., Martini, F., and Petruzzelli, R. (1977). The structure of mitochondrial aspartate aminotransferase from pigheart and comparison with that of the cytoplasmic isozyme. FEBS Lett. 83241.
Bobrow, M., and Cross, J. (1975). Differential staining of human and mouse chromosomes in interspecific cell hybrids. Nature 25177.
Caspersson, T., Zech, L., Harris, H. Wiener, F., and Klein, G. (1971). Identification of human chromosomes in a mouse/human hybrid by fluorescence techniques. Exp. Cell Res. 65475.
Creagan, R., Tischfield, J., McMorris, F. A., Chen, S., Hirschi, M., Chen, T. R., Ricciuti, F., and Ruddle, F. H. (1973). Assignment of the genes for human peptidase A to chromosome 18 and cytoplasmic glutamate oxaloacetate transmainase to chromosome 10 using somatic cell hybrids. Cytogenet. Cell Genet. 12187.
Craig, I. W., Tolley, E., Bobrow, M., and van Heyningen, V. (1977). Assignment of a gene necessary for the expression of mitochondrial glutamic-oxaloacetic transaminase in human-mouse hybrid cells. Fourth International Workshop on Human Gene Mapping. Birth Defects Orig. Art. Ser 14190.
Edwards, Y. H., and Hopkinson, D. A. (1979). The genetic determination of fumarase isozymes in human tissues. Ann. Hum. Genet. 42303.
Jones, E. A., Goodfellow, P. N., Kennett, R. H., and Bodmer, W. F. (1976). The independent expression of HLA and β2-microglobin on human-mouse hybrids. Somat. Cell Genet. 2483.
Kagamiyama, H., Sakakibara, R., Wada, H., Tanasa, S., and Morino, Y. (1977). The complete amino acid sequences of mitochondrial aspartate aminotransferase from pig heart. J. Biochem. 82291.
Lalley, P. A., Francke, U., and Minna, J. D. (1978). Comparative gene mapping; The linkage relationships of the homologous genes for phosphoglucomutase and peptidase S are conserved in man and mouse. Cytogenet. Cell Genet. 22570.
Nabholz, M. (1969). D.Phil. thesis, Stanford University.
Nabholz, M., Miggiano, V., and Bodmer, W. (1969). Genetic analysis with human-mouse somatic cell hybrids. Nature 222358.
Orkwiszewski, K. G., Tadesco, T. A., and Croce, C. M. (1974). Assignment of the human gene for galactokinase to chromosome 17. Nature 25260.
Ruddle, F. H. (1973). Linkage analysis in man by somatic cell genetics. Nature 242165.
Santachiara, A. S., Nabholz, M., Miggiano, V., Darlington, A. J., and Bodmer, W. (1970). Genetic analysis with man-mouse somatic cell hybrids. Nature 227248.
Solomon, E., Bobrow, M., Goodfellow, P. N., Bodmer, W. F., Swallow, D. M., Povey, S., and Noël, B. (1976). Human gene mapping using an X/autosome translocation. Som. Cell Genet. 2125.
Sonderegger, P., and Christen, P. (1978). Comparison of the evolution rates of cytosolic and mitochondrial aspartate aminotransferase. Nature 275157.
Teranishi, H., Kagamiyama, H., Teranishi, D., Wada, H., Yamano, T., and Morino, Y. (1978). Cytosolic and mitochondrial isoenzymes of glutamic oxalacetic transaminase from human heart: Structural comparison with the isoenzymes from pigheart. J. Biol. Chem. 2538842.
Tischfield, J. A., and Ruddle, F. (1974). Assignment of the gene for adenine phosphoribosyl-transferase to human chromosome 16 by mouse-human somatic cell hybridization. Proc. Natl. Acad. Sci. 7145.
Tolley, E. (1977). M.Sc. thesis, Oxford University.
Tolley, E., and Craig, I., (1975). Presence of two forms of fumarase (fumarate hydratase E.C. 4.2.1.2.) in mammalian cells: Immunological characterization and genetic analysis in somatic cell hybrids. Confirmation of the assignment of a gene necessary for the enzyme expression to human chromosome 1. Biochem. Genet. 13867.
van Heyningen, V. (1973). D.Phil. thesis, Oxford University.
van Heyningen, V., Craig, I. W., and Bodmer, W. F. (1973). Genetic control of mitochondrial enzymes in human-mouse somatic cell hybrids. Nature 242509.
van Heyningen, V., Craig, I. W., and Bodmer, W. F. (1974). Mitochondrial enzymes in man-mouse hybrid cells. In Kroon, A. M., and Saccone, C. (eds.), The Biogenesis of Mitochondria Academic Press, New York, p. 231.
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Tolley, E., van Heyningen, V., Brown, R. et al. Assignment to chromosome 16 of a gene necessary for the expression of human mitochondrial glutamate oxaloacetate transaminase (aspartate aminotransferase) (E.C. 2.6.1.1.). Biochem Genet 18, 947–954 (1980). https://doi.org/10.1007/BF00500127
Received:
Revised:
Issue Date:
DOI: https://doi.org/10.1007/BF00500127