Summary
Gamma-amino-beta-hydroxybutyric acid (GABOB), injected intraperitoneally in rats at the dose of 0.5 g/kg, causes a significant decrease of brain serotonin, and proves different from other anticonvulsant drugs in this respect.
This is a preview of subscription content, log in via an institution to check access.
References
Bonnycastle, D. D., N. J. Giarman and M. K. Paarsonen: Anticonvulsant compounds and 5-hydroxytryptamine in rat brain. Brit. J. Pharmacol. 12, 228–231 (1956).
Buscaino, G. A., e E. Ferrari: Prime esperienze cliniche ed elettroencef alografiche sulla efficacia antiepilettica del GABOB e dell'Elipten. Acta neurol. (Napoli) 16, 748–771 (1961).
DeMaio, D., A. Madeddu e L. Faggioli: Gli acidi gamma-aminobutirrico (GABA) e gamma-amino-beta-idrossibutirrico (GABOB) nella prospettiva di una terapia biologica antioomiziale. Acta neurol. (Napoli) 16, 366–406 (1961).
Erspamer, V.: Some observations on fate of exogenous 5-hydroxytryptamine (enteramine) in rat. J. Physiol. 133, 1–9 (1956).
Floris, V., C. Morocutti, N. Gaggini e A. Napoleone Capra: Riflessi clinici delle recenti acquisizioni sui fenomeni di inibizione nel sistema nervoso. Riv. Neurobiol. 7, 824–888 (1961).
Hayashi, T.: Inhibition in the nervous system and gamma-amino butyric acid, p. 515. London: Pergamon Press 1960.
Roberts, E., M. Rothstein and F. Baxter: Some metabolic studies of gammaaminobutyric acid. Proc. Soc. exp. Biol. (N.Y.) 97, 796–802 (1958).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
De Maio, D., Pasquariello, G. Gamma-amino-beta-hydroxybutyric acid (GABOB) and brain serotonin. Psychopharmacologia 5, 84–86 (1963). https://doi.org/10.1007/BF00405577
Received:
Issue Date:
DOI: https://doi.org/10.1007/BF00405577