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High production of 1,3-propanediol from glycerol by Clostridium butyricum VPI 3266 in a simply controlled fed-batch system

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Summary

A simple fed-batch system which controls substrate feeding by measuring the CO2 produced during the fermentation, was developped. This Fed-batch approach allowed high production of 1,3-propanediol from glycerol by Clostridium butyricum by avoiding substrate inhibition phenomena. 65 g/l of 1,3-propanediol was produced with a productivity of 1.21 g/l.h and a yield of 0.56. The concentration of 1,3-propanediol obtained and the productivity were significantly higher than those reached in batch culture.

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Authors and Affiliations

  1. Institut National des Sciences Appliquées, Centre de Bioingénierie Gilbert Durand, URA CNRS 544, L.A.INRA. Complexe Scientifique de Rangueil, 31077, Toulouse Cedex, France

    S. Saint-Amans, P. Perlot, G. Goma & P. Soucaille

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  1. S. Saint-Amans
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  2. P. Perlot
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  3. G. Goma
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  4. P. Soucaille
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Saint-Amans, S., Perlot, P., Goma, G. et al. High production of 1,3-propanediol from glycerol by Clostridium butyricum VPI 3266 in a simply controlled fed-batch system. Biotechnol Lett 16, 831–836 (1994). https://doi.org/10.1007/BF00133962

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  • DOI: https://doi.org/10.1007/BF00133962

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