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Toxicology- From Cells to Man

Proceedings of the 1995 EUROTOX Congress Meeting Held in Prague, Czech Republic, August 27–l30, 1995

  • Conference proceedings
  • © 1996

Overview

Editors:
  1. Jürg P. Seiler

    1. Interkantonale Kontrollstelle für Heilmittel, Bern 9, Switzerland

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  2. Olga Kroftová

    1. Department of Pharmacology, Charles University of Prague, Ruská 87, Czech Republic

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    You can also search for this editor in PubMed   Google Scholar

  3. Vladislav Eybl

    1. Department of Pharmacology, Charles University, Faculty of Medicine, Pilsen, Czech Republic

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    You can also search for this editor in PubMed   Google Scholar

Part of the book series: Archives of Toxicology (TOXICOLOGY, volume 18)

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Table of contents (40 papers)

  1. Front Matter

    Pages I-IX
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  2. The Gerhard Zbinden Memorial Lecture

    1. Front Matter

      Pages 1-1
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    2. Alteration of Cell Signalling in Chemical Toxicity

      • Pierluigi Nicotera
      Pages 3-11

  3. Human Immunotoxicology and the Environment

    1. Front Matter

      Pages 13-13
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    2. Halogenated Organic Compounds and the Human Immune System:Preliminary Report on a Study in Hobby Fishermen

      • M. Løvik, H. R. Johansen, P. I. Gaarder, G. Becher, I. S. Aaberge, W. Gdynia et al.
      Pages 15-20

    3. Risk Assessment for the Harmful Effects of UVB Radiation on the Immunological Resistance to Infectious Diseases

      • Henk Van Loveren, Wim Goettsch, Wout Slob, Johan Garssen
      Pages 21-28

    4. Sentinel Screening for Human Immunotoxicity

      • J. Descotes, B. Nicolas, E. Pham, T. Vial
      Pages 29-33

    5. Impact of Environmental Pollution on Respiratory Sensitization and Asthma

      • I. Kimber
      Pages 34-48

  4. Functional Teratogenicity

    1. Front Matter

      Pages 49-49
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    2. Introduction to Functional Teratology

      • L. Dencker
      Pages 51-56

    3. The Neurobehavioural Toxicology and Teratology of Lead

      • Gerhard Winneke, Hellmuth Lilienthal, Ursula Krämer
      Pages 57-70

    4. Teratogenic Effects of Alcohol:Current Status of Animal Research and in vitro Models

      • Consuelo Guerri
      Pages 71-80

    5. Developmental Neurotoxicology in the Neonate - Effects of Pesticides and Polychlorinated Organic Substances

      • P. Eriksson
      Pages 81-88

    6. Drug Treatment in the Perinatal Period and the Risk of Functional Teratogenicity

      • O. Benešová
      Pages 89-96

    7. The Effects on Mammals of Pre- and Postnatal Environmental Exposure to PCBs1 The Dutch Collaborative PCB/Dioxin Study

      • A. E. Smits-van Prooije, D. H. Waalkens-Berendsen, D. C. Morse, C. Koopman-Esseboom, M. Huisman, P. J. J. Sauer et al.
      Pages 97-102

  5. Intercellular Communication

    1. Front Matter

      Pages 103-103
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    2. Connexin Genes and Cell Growth Control

      • H. Yamasaki, V. Krutovskikh, M. Mesnil, Y. Omori
      Pages 105-114

    3. Disruption of Polarized Function in Hepatocytes

      • J. K. Chipman, R. Coleman, J. C. Wilton, M. J. Guppy, V. Stone, D. J. Lankester
      Pages 115-126

    4. Cytokines in human lung fibrosis

      • Yves Martinet, Olivier Menard, Pierre Vaillant, Jean-Michel Vignaud, Nadine Martinet
      Pages 127-139

    5. The Glio-Vascular Toxicity of m -Dinitro- Benzene and Related Agents: Modulation of Toxicity by Neuronal Activation

      • D. E. Ray, J. L. Holton, T. Lister, C. C. Nolan
      Pages 140-148
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Keywords

About this book

Renal transport and xenobiotic metabolism play an important role in the detoxication and excretion of potentially toxic xenobiotics. However, recent experimental evidence has demonstrated that renal xenobiotic metabolism and renal transport processes also play an important role in the nephrotoxicity of xenobiotics and xenobiotic metabolites. The high blood flow to the kidney combined with its ability to concentrate solutes may expose the kidney to high concentrations of xenobiotics and xenobiotics metabolites present in the systemic circulation. Recently, it has been demonstrated that xenobiotic metabolites formed in the liver and other organs may be targeted to the kidney by selective transport systems~ many xenobiotics require enzymatic transformation to proximate reactive metabolites to elicit their toxic and carcinogenic effects. The enzymatic formation of reactive metabolites is termed bioactivation. The bioactivation mechanisms for many nephrotoxicants have, at least in part, been elucidated in the past 15 years. Many ultimate toxicants formed in the kidney are electrophiles whose interaction with cellular macromolecules may cause a perturbation of normal cell function resulting in necrosis and/or cancer (Anders 1988). Electrophilic metabolites may bind to nucleophilic sites in cellular macromolecules~ the importance of covalent modification of protein and DNA in cell killing and in the induction of tumors is established (Miller and Miller 1981~ Nelson and Pearson 1990~ Hinson and Roberts 1992). The objective of this review is to summarize new information about renal transport, renal bioactivation and their relation to nephrotoxicity using two relevant example for the basic mechanisms outlined above.

Editors and Affiliations

  • Interkantonale Kontrollstelle für Heilmittel, Bern 9, Switzerland

    Jürg P. Seiler

  • Department of Pharmacology, Charles University of Prague, Ruská 87, Czech Republic

    Olga Kroftová

  • Department of Pharmacology, Charles University, Faculty of Medicine, Pilsen, Czech Republic

    Vladislav Eybl

Bibliographic Information

  • Book Title: Toxicology- From Cells to Man

  • Book Subtitle: Proceedings of the 1995 EUROTOX Congress Meeting Held in Prague, Czech Republic, August 27–l30, 1995

  • Editors: Jürg P. Seiler, Olga Kroftová, Vladislav Eybl

  • Series Title: Archives of Toxicology

  • DOI: https://doi.org/10.1007/978-3-642-61105-6

  • Publisher: Springer Berlin, Heidelberg

  • eBook Packages: Springer Book Archive

  • Copyright Information: Springer-Verlag Berlin Heidelberg 1996

  • Softcover ISBN: 978-3-642-64696-6Published: 22 September 2011

  • eBook ISBN: 978-3-642-61105-6Published: 06 December 2012

  • Series ISSN: 0171-9750

  • Edition Number: 1

  • Number of Pages: IX, 441

  • Topics: Pharmacology/Toxicology, Immunology, Biochemistry, general

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