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Mos and the cell cycle

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Progress in Cell Cycle Research

Part of the book series: Progress in Cell Cycle Research ((PCCR))

Abstract

The mos proto-oncogene-encoded serine/threonine protein kinase plays a key cell cycle-regulatory role during meiosis. The Mos protein is required for the activation and stabilisation of M phase-promoting factor MPF. As a component of a large multiprotein complex known as the cytostatic factor (CSF), Mos is involved in causing metaphase II arrest of eggs in vertebrates. Upon expression in somatic cells, Mos causes cell cycle perturbations resulting in cytotoxicity and neoplastic transformation. All the known biological activities of Mos are mediated through activation of the mitogen activated protein (MAP) kinase pathway. Here we discuss the interrelationship between Mos and other cell cycle regulators.

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Authors and Affiliations

  1. Department of Molecular Pathology, The University of Texas M. D. Anderson Cancer Center, Box 172, 1515 Holcombe Blvd., Houston, TX, 77030, USA

    Balraj Singh & Ralph B. Arlinghaus

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  1. Balraj Singh
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  2. Ralph B. Arlinghaus
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  1. Centre National de la Recherche Scientifique, Roscoff, France

    Laurent Meijer  & Silvana Guidet  & 

  2. Centre National de la Recherche Scientifique, Université de Rennes I, Rennes, France

    Michel Philippe

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Singh, B., Arlinghaus, R.B. (1997). Mos and the cell cycle. In: Meijer, L., Guidet, S., Philippe, M. (eds) Progress in Cell Cycle Research. Progress in Cell Cycle Research. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-5371-7_20

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  • DOI: https://doi.org/10.1007/978-1-4615-5371-7_20

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