Abstract
Neuropeptide B (NPB) and neuropeptide W (NPW) are neuropeptides that were recently identified as endogenous ligands for the previously orphan G-protein coupled receptors, GPR7 (NPBWR1) and GPR8 (NPBWR2). This neuropeptide system is thought to have a role in regulating feeding behavior, energy homeostasis, neuroendocrine function, and modulating inflammatory pain. Strong and discrete expression of their receptors in the extended amygdala suggests a potential role in regulating stress responses, emotion, anxiety and fear; however, there have been no functional studies to date to support this possibility. Future studies of NPB/NPW using both pharmacological and phenotypic analysis of genetically engineered mice will lead to further elucidation of the physiological role of this novel neuropeptide system.
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Hondo, M., Ishii, M., Sakurai, T. (2008). The NPB/NPW Neuropeptide System and Its Role in Regulating Energy Homeostasis, Pain, and Emotion. In: Civelli, O., Zhou, QY. (eds) Orphan G Protein-Coupled Receptors and Novel Neuropeptides. Results and Problems in Cell Differentiation, vol 46. Springer, Berlin, Heidelberg. https://doi.org/10.1007/400_2007_056
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DOI: https://doi.org/10.1007/400_2007_056
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