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Brain Repair pp 25–53Cite as

DSD-1-Proteoglycan/Phosphacan and Receptor Protein Tyrosine Phosphatase-Beta Isoforms during Development and Regeneration of Neural Tissues

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Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 557))

Summary

Interactions between neurons and glial cells play important roles in regulating key events of development and regeneration of the CNS. Thus, migrating neurons are partly guided by radial glia to their target, and glial scaffolds direct the growth and directional choice of advancing axons, e.g., at the midline. In the adult, reactive astrocytes and myelin components play a pivotal role in the inhibition of regeneration. The past years have shown that astrocytic functions are mediated on the molecular level by extracellular matrix components, which include various glycoproteins and proteoglycans. One important, developmentally regulated chondroitin sulfate proteoglycan is DSD-1-PG/phosphacan, a glial derived proteoglycan which represents a splice variant of the receptor protein tyrosine phosphatase (RPTP)-beta (also known as PTP-zeta). Current evidence suggests that this proteoglycan influences axon growth in development and regeneration, displaying inhibitory or stimulatory effects dependent on the mode of presentation, and the neuronal lineage. These effects seem to be mediated by neuronal receptors of the Ig-CAM superfamily.

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Authors and Affiliations

  1. Department of Cell Morphology and Molecular Neurobiology, Ruhr-University, Bochum, Germany

    Andreas Faissner

  2. Institute of Physiology and Pathophysiology, University of Mainz, Mainz, Germany

    Nicolas Heck

  3. INSERM U686, Centre Universitaire des Saints-Péres, Paris, France

    Alexandre Dobbertin

  4. Centre de Neurochimie du CNRS, Strasbourg, France

    Jeremy Garwood

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  1. Andreas Faissner
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  2. Nicolas Heck
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  3. Alexandre Dobbertin
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  4. Jeremy Garwood
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Editors and Affiliations

  1. Department of Neurology, University of Göttingen, Göttingen, Germany

    Mathias Bähr

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Faissner, A., Heck, N., Dobbertin, A., Garwood, J. (2006). DSD-1-Proteoglycan/Phosphacan and Receptor Protein Tyrosine Phosphatase-Beta Isoforms during Development and Regeneration of Neural Tissues. In: Bähr, M. (eds) Brain Repair. Advances in Experimental Medicine and Biology, vol 557. Springer, Boston, MA. https://doi.org/10.1007/0-387-30128-3_3

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