Regular ArticleEVIDENCE FOR OXIDATIVE STRESS IN THE HEPATIC MITOCHONDRIA OF BILE DUCT LIGATED RATS
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Mitochondria protection as a mechanism underlying the hepatoprotective effects of glycine in cholestatic mice
2018, Biomedicine and PharmacotherapyCitation Excerpt :In the current study, we found that cholestasis caused a vast oxidative stress as well as significant mitochondrial dysfunction in the liver. The involvement of mitochondrial dysfunction in the pathogenesis of bile acid-induced liver injury has been reported [2,10,64,74,75]. Bile acid-induced mitochondrial permeability transition (mPT) play a critical role in their mechanism of cytotoxicity [2,64,75].
Protective effects of a polymethoxy flavonoids-rich Citrus aurantium peel extract on liver fibrosis induced by bile duct ligation in mice
2016, Asian Pacific Journal of Tropical MedicineCitation Excerpt :The extent of attenuation by CAE was higher than that of silymarin (200 mg/kg). Furthermore, it has been known that oxidative stress is one of the main contributors in cholestatic liver disease [24]. During liver cholestasis, oxidative stress occurs.
The effects of obstructive jaundice on the brain: An experimental study
2016, Asian Journal of SurgeryCitation Excerpt :Therefore, MDA formation is the indicator for lipid peroxidation. Different studies showing an increase of MDA levels in experimental models of OJ confirms our results.17,18 Free oxygen radicals are formed from oxygen, which is used in mitochondria, in order to provide energy for brain tissues.
Artemisia capillaris extract protects against bile duct ligation-induced liver fibrosis in rats
2013, Experimental and Toxicologic PathologyCitation Excerpt :MDA is a biomarker for lipid peroxidation generated by ROS, which are critically controlled by NOX, the reduced form of NADPH oxidase (Cui et al., 2011; Levitan et al., 2010). NO is a typical indicator of reactive oxygen species (ROS), and lipid peroxidation is an indicator of oxidative stress in the BDL model (Alptekin et al., 1997; Desmet et al., 1995; Fujita et al., 2003). Immunochemistry staining against 4-HNE demonstrated the lipid peroxidation inside cells (Poli and Schaur, 2000), and BDL treatment strongly enhanced the 4-HNE expression compared to the sham group.
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