Fibronectin Domains of Extracellular Matrix Molecule Tenascin-C Modulate Hippocampal Learning and Synaptic Plasticity

doi:10.1006/mcne.2002.1172

Molecular and Cellular Neuroscience

Volume 21, Issue 1, September 2002, Pages 173-187

https://doi.org/10.1006/mcne.2002.1172 Get rights and content

Abstract

The extracellular matrix molecule tenascin-C (TN-C) has been shown to be involved in hippocampal synaptic plasticity in vitro. Here, we describe a deficit in hippocampus-dependent contextual memory in TN-C-deficient mice using the step-down avoidance paradigm. We further show that a fragment of TN-C containing the fibronectin type-III repeats 6–8 (FN6-8), but not a fragment containing repeats 3–5, bound to pyramidal and granule cell somata in the hippocampal formation of C57BL/6J mice and repelled axons of pyramidal neurons when presented as a border in vitro. Injection of the FN6-8 fragment into the hippocampus inhibited retention of memory in the step-down paradigm and reduced levels of long-term potentiation in the CA1 region of the hippocampus. In summary, our data show that TN-C is involved in hippocampus-dependent contextual memory and synaptic plasticity and identify the FN6-8 domain as one of molecular determinants mediating these functions.

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¹: These authors contributed equally to this work.

²: These authors contributed equally to this work.

³: To whom correspondence should be addressed. Fax: +49-40-42 80 36 24 8. E-mail: [email protected].

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Regular ArticleFibronectin Domains of Extracellular Matrix Molecule Tenascin-C Modulate Hippocampal Learning and Synaptic Plasticity

Abstract

J. Biol. Chem.

Prog. Neurobiol.

Neuroscience.

Brain Res. Mol. Brain Res.

Semin. Dev. Biol.

Neurobiol. Learn. Memory

Behav. Neural Biol.

Matrix Biol.

J. Pharmacol. Methods

Pharmacol. Biochem. Behav.

Behav. Brain Res.

Mol. Cell. Neurosci.

Mol. Cell. Neurosci.

Behav. Neural Biol.

Expression of tenascin in the developing and adult cerebellar cortex

J. Neurosci.

Involvement of hippocampal AMPA glutamate receptor changes and the cAMP/protein kinase A/CREB-P signalling pathway in memory consolidation of an avoidance task in rats

Braz. J. Med. Biol. Res.

Learning-specific, time-dependent increases in hippocampal Ca2+/calmodulin-dependent protein kinase ll activity and AMPA GluR1 subunit immunoreactivity

Eur. J. Neurosci.

The tenascin gene family

Perspect. Dev. Neurobiol.

Contribution of voltage-gated Ca2+ channels to homosynaptic long-term depression in the CA1 region in vitro

J. Neurophysiol.

Distinct effects of recombinant tenascin-C domains on neuronal cell adhesion, growth cone guidance, and neuronal polarity

J. Neurosci. Res.

Intraventricular infusions of anti-neural cell adhesion molecules in a discrete posttraining period impair consolidation of a passive avoidance response in the rat

J. Neurochem.

Mice deficient in the polysialyltransferase ST8SialV/PST-1 allow discrimination of the roles of neural cell adhesion molecule protein and polysialic acid in neural development and synaptic plasticity

J. Neurosci.

Evolution of the tenascin family—Implications for function of the C-terminal fibrinogen-like domain

Perspect. Dev. Neurobiol.

Impairment of voltage-gated Ca2+ channel-dependent forms of hippocampal synaptic plasticity in mice deficient in the extracellular matrix glycoprotein tenascin-C

J. Neurosci.

Tenascin and janusin: Glial recognition molecules involved in neural development and regeneration

Neuroglia

Regular Article
Fibronectin Domains of Extracellular Matrix Molecule Tenascin-C Modulate Hippocampal Learning and Synaptic Plasticity

Learning-specific, time-dependent increases in hippocampal Ca²⁺/calmodulin-dependent protein kinase ll activity and AMPA GluR1 subunit immunoreactivity

Contribution of voltage-gated Ca²⁺ channels to homosynaptic long-term depression in the CA1 region in vitro

Impairment of voltage-gated Ca²⁺ channel-dependent forms of hippocampal synaptic plasticity in mice deficient in the extracellular matrix glycoprotein tenascin-C