Elsevier

Hormones and Behavior

Volume 37, Issue 2, March 2000, Pages 145-155
Hormones and Behavior

Regular Article
Infant Vocalization, Adult Aggression, and Fear Behavior of an Oxytocin Null Mutant Mouse

https://doi.org/10.1006/hbeh.1999.1566Get rights and content

Abstract

Previous studies have shown that oxytocin (OT)-deficient female mice produced by homologous recombination fail to lactate but exhibit normal parturition and reproductive behaviors. We examined the ultrasonic vocalizations of infant mice and the subsequent aggressive and fear behavior of adult male OT knockout (OT-KO) mice. Infant OT-KO mice were less vocal than wild-type (WT) control mice during separations from the mother and peers. Adult OT-KO males were generally more aggressive in isolation-induced and resident–intruder tests of aggression and less fearful in the plus maze and acoustic startle reflex tests than WT controls. Although the increase in tests of aggression was robust for OT-KO males from obligate litters (progeny of homozygous × homozygous crossings), the increase in aggression was reduced during tests for OT-KO males derived from nonobligate mating (progeny of heterozygous × heterozygous crossings), suggesting that the OT-KO genotype was not, by itself, responsible for the changes in adult behavior. We conclude that the absence of exposure to OT during development was associated with abnormalities in the development of emotional behavior.

References (40)

  • J.-L. Moreau et al.

    Behavioral profile of the 5HT(1A) receptor antagonist (S)-UH-301 in rodents and monkeys

    Brain Res. Bull.

    (1992)
  • H.P. Oosterbaan et al.

    Amniotic oxytocin and vasopressin in relation to human fetal development and labor

    Early Hum. Dev.

    (1989)
  • R.J. Rodgers et al.

    Influence of social isolation, gender, strain, and prior novelty on plus-maze behaviour in mice

    Physiol. Behav.

    (1993)
  • L.J. Young et al.

    Gene targeting approaches to neuroendocrinology: Oxytocin, maternal behavior, and affiliation

    Horm. Behav.

    (1997)
  • O. Berton et al.

    Behavioral reactivity to social and nonsocial stimulations: A multivariate analysis of six inbred rat strains

    Behav. Genet.

    (1997)
  • A.M. Burton et al.

    Placental transfer of oxytocin in the guinea-pig and its release during parturition

    J. Endocrinol.

    (1974)
  • J.N. Crawley et al.

    Behavioral phenotypes of inbred mouse strains: Implications and recommendations for molecular studies

    Psychopharmacology

    (1997)
  • A.C. DeVries et al.

    Reduced aggressive behavior in mice with targeted disruption of the oxytocin gene

    J. Neuroendocrinol.

    (1997)
  • C.F. Ferris et al.

    Oxytocin in the amygdala facilitates maternal aggression

    Ann. N.Y. Acad. Sci.

    (1992)
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