Elsevier

Genomics

Volume 80, Issue 2, August 2002, Pages 204-212
Genomics

Regular Article
Tnfrsf13c (Baffr) is Mis-expressed in Tumors with Murine Leukemia Virus Insertions at Lvis22

https://doi.org/10.1006/geno.2002.6812Get rights and content

Abstract

In susceptible strains of mice, leukemia is caused by the somatic integration of murine leukemia retroviruses into the host genome. Integration sites that are common to several tumors are likely to affect genes that are important in oncogenesis. Here we present the analysis of a common site of retroviral integration on mouse chromosome 15, which includes the genomic structure of three genes near the integration site. One of the genes misexpressed at the insertion site has recently been characterized as a B-cell receptor, Tnfrsf13c (formerly Baffr), indicating that this approach is useful in defining genes that function in lymphocyte development and tumor progression. Current genome databases provide powerful resources for the rapid identification of genes at common proviral insertion sites. The characterization of these genes in tumor samples will allow a function to be assigned to many novel loci identified by the genome sequencing projects.

References (16)

  • D.J. Gilbert et al.

    Susceptibility of AKXD recombinant inbred mouse strains to lymphomas

    J. Virol.

    (1993)
  • M.L. Mucenski et al.

    Comparative molecular genetic analysis of lymphomas arising from six inbred mouse strains

    J. Virol.

    (1988)
  • M.L. Mucenski et al.

    Common sites of viral integration in lymphomas arising in AKXD recombinant inbred mouse strains

    Oncogene Res.

    (1987)
  • M.L. Mucenski et al.

    AKXD recombinant inbred strains: models for studying the molecular genetic basis of murine lymphomas

    Mol. Cell. Biol.

    (1986)
  • G.M. Hansen et al.

    Genetic profile of insertion mutations in mouse leukemias and lymphomas

    Genome Res.

    (2000)
  • J.S. Thompson

    BAFF-R, a newly identified TNF receptor that specifically interacts with BAFF

    Science

    (2001)
  • P. Schneider

    BAFF, a novel ligand of the tumor necrosis factor family, stimulates B-cell growth

    J. Exp. Med.

    (1999)
There are more references available in the full text version of this article.

Cited by (5)

  • The PANE1 gene encodes a novel human minor histocompatibility antigen that is selectively expressed in B-lymphoid cells and B-CLL

    2006, Blood
    Citation Excerpt :

    The gene located closest to PANE1 on chromosome 22q (12 kb from its 5′ terminus) is TNFRSF13C, which encodes a member of the tumor necrosis factor (TNF) receptor superfamily that, like PANE1 transcript k, is selectively expressed in resting CD19+ B cells.36,37 The murine homologs of PANE1 and TNFRSF13C are likewise immediately adjacent to one another in the syntenic region of the mouse genome on chromosome 15.38 The product of the human TNFRSF13C gene, also known as BAFF-R—B-cell activation factor receptor—encodes a membrane-bound receptor for BAFF (B-cell activation factor), and is the principal receptor for BAFF-mediated mature B-cell survival.

*

To whom correspondence and reprint requests should be addressed. Fax: (713) 798-1489. E-mail: [email protected]

View full text