Regular ArticleDistribution of Glutamate Receptor Subunit NMDAR1 in the Hippocampus of Normal Elderly and Patients with Alzheimer's Disease
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2017, Journal of Chromatography B: Analytical Technologies in the Biomedical and Life SciencesCitation Excerpt :As a result, the content of d-Ser in hippocampus and cortex in AD group was lower than normal group. Due to the fact that the regional distribution of d-Ser in brain co-localized almost the same with NMDARs, poor distribution of d-Ser in hippocampus and cortex in AD patients could contribute to the reduction of the number of NMDARs, causing gradual damage in function and structure in brain, especially in hippocampus [28]. Previous studies have also found the release of d-Ser was activated by Ca2+ influx through NMDARs in synaptic transmission.
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2013, NeuronCitation Excerpt :If the mechanisms described here for CD36 and Trem2 recycling are used more widely, it is tempting to speculate that beclin 1 deficiency might also result in dysfunctional turnover and availability of other membrane receptors. Notably, receptors for various growth factors or NMDA are dysregulated in AD (Ikonomovic et al., 1999; Moloney et al., 2010; Tesseur et al., 2006). Additionally, beclin 1 has been shown to be associated with several surface receptors, including delta 2 glutamate receptors (Yue et al., 2002) and bacterial SLAM receptors (Berger et al., 2010; Ma et al., 2012).
EphBs: An integral link between synaptic function and synaptopathies
2012, Trends in NeurosciencesCitation Excerpt :A reduction in synapse density in the cortex and hippocampus is found during the onset of AD and correlates with the level of cognitive impairment [5,104]. EphB and NMDAR subunit expression are both reduced early in AD progression [42,105,106]. Furthermore, there are reduced levels of GluN2 subunit phosphorylation in postmortem brain samples from patients with AD [106].
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2012, Progress in NeurobiologyActivation of D1/D5 dopamine receptors protects neurons from synapse dysfunction induced by amyloid-β oligomers
2011, Journal of Biological ChemistryCitation Excerpt :Among several aspects of synapse function reported to be affected by AβOs is the internalization of AMPA and NMDA receptors. Both receptors exhibit reduced surface levels upon in vitro exposure of neurons to different AβO preparations and reduced total levels in transgenic mouse models of AD and in AD brains (10–14, 33–35). AMPA and NMDA receptors are essential for glutamatergic synaptic transmission and play key roles in LTP and LTD, cellular mechanisms of plasticity thought to underlie learning, memory, and cognition (36).