Regular ArticleThe Lipid Peroxidation Product 4-Hydroxynonenal Impairs Glutamate and Glucose Transport and Choline Acetyltransferase Activity in NSC-19 Motor Neuron Cells☆
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2017, Free Radical Biology and MedicineCitation Excerpt :Aggregation and accumulation of the mutant SOD1 occurs in the motor neurons of anterior horns in fALS patients in the form of hyaline inclusions, which contain epitopes of ubiquitin and phosphorylated neurofilaments [76]. An in vitro study showed that HNE impairs the glutamate and glucose transport and the choline acetyltransferase activity in cultured motor neurons [77], while human autopsy materials have shown increased levels of HNE, which modifies astrocytic glutamate transporter EAAT2 impairing glutamate transport in ALS. In sALS patients HNE was found to be increased in spinal motor neurons of the ventral horn [78], in which strong immunoreactivity for HNE adducts with epsilon-n-carboxymethyl lysine present in the cytoplasm of the degenerated motor neurons suggests involvement of HNE in ALS, while acrolein was not detected in the spinal cord of ALS patients [79].
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W. WascoR. E. Tanzi