Regular ArticleNeurotrophins and Their Receptors—Current Concepts and Implications for Neurologic Disease
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2012, Neurochemistry InternationalCitation Excerpt :Interaction of neurotrophin to Trk receptors promotes cell growth, survival or differentiation while binding of neurotrophin to p75NTR have been widely known to be involved in cell death mechanism mainly apoptosis (Bibel and Barde, 2000; Chao, 2003). The association between neurotrophin and p75NTR/Trk heterodimer interactions could result in either cell survival or cell death (Eide et al., 1993; Friedman and Green, 1999). Although NGF was first discovered in snake venoms (Cohen and Levi-Montalcini, 1956), the NGFs isolated from the mouse submaxillary glands (mouse NGF; Lipps, 1998) and human placental tissues and body fluids have been studied extensively (Goldstein et al., 1978 and Lipps, 2000).
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2007, Journal of Biological ChemistryNeural Upregulation in Interstitial Cystitis
2007, UrologyCitation Excerpt :These studies support neurologic changes to the micturition reflex pathway after cystitis. Changes to central synapses lead to enhanced pain sensation.80–82 The pontine micturition center (PMC) connects with axon collaterals to the paraventricular thalamic nucleus (limbic system).