Special ArticleYeast Pre-mRNA Is Composed of Two Populations with Distinct Kinetic Properties
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Cotranscriptional spliceosome assembly occurs in a stepwise fashion and requires the cap binding complex
2005, Molecular CellCitation Excerpt :Evidence accumulating from metazoan systems indicates that pre-mRNA splicing is cotranscriptional (Neugebauer, 2002). Although cotranscriptional pre-mRNA splicing has never been directly demonstrated in yeast, two previous studies are suggestive: in one, the kinetics of appearance of spliced mRNA were examined and favored concurrent splicing and transcription (Elliott and Rosbash, 1996), and in another, the U1 snRNP was shown to be cotranscriptionally recruited to intron-containing genes on a genome-wide scale (Kotovic et al., 2003). The data presented here on Prp19p further suggest that splicing can occur cotranscriptionally in yeast.
Review: Movement of mRNA from transcription site to nuclear pores
2000, Journal of Structural BiologyGenome-wide analysis of mRNA lengths in Saccharomyces cerevisiae
2003, Genome BiologyCotranscriptional recruitment of the U1 snRNP to intron-containing genes in yeast
2003, Molecular and Cellular Biology
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Present address: MRC Human Genetics Unit, Chromosome Biology Section, Western General Hospital, Crewe Road, Edinburgh EH4 2XU, Scotland.
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