Biochemical and Biophysical Research Communications
Regular ArticleCloning, Expression, and Mapping of a Gene That Is Upregulated in Adipose Tissue of Mice Deficient in Bombesin Receptor Subtype-3
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Loss of DRO1/CCDC80 results in obesity and promotes adipocyte differentiation
2017, Molecular and Cellular EndocrinologyTranscriptional repression of the tumor suppressor DRO1 by AIB1
2011, FEBS LettersCitation Excerpt :Elucidating the pathways underlying an oncogene or tumor suppressor is a key to find new strategies for improving cancer therapy. The gene coiled-coil domain containing 80 (i.e. CCDC80, also called DRO1, URB, SSG1 and equarin) was identified as upregulated in brown adipose tissue of mice deficient in bombesin receptor subtype-3 [1]. Further studies revealed to be abundantly expressed in fat and deregulated in obesity [2], regulating adipogenesis through the down-regulation of Wnt/β-catenin signalling and induction of C/EBPα and PPARγ [3].
Bidirectional modulation of adipogenesis by the secreted protein Ccdc80/DRO1/URB
2009, Journal of Biological ChemistryURB is abundantly expressed in adipose tissue and dysregulated in obesity
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To whom correspondence and reprint requests should be addressed at Department of Degenerative Neurological Diseases, National Institute of Neuroscience, National Center of Neurology and Psychiatry, 4-1-1 Ogawahigashi, Kodaira, Tokyo 187-8502, Japan. Fax: +81-42-346-1745. E-mail: [email protected].