Biochemical and Biophysical Research Communications
Regular ArticleThe N-Terminal Tandem Repeat Region of Human Prion Protein Reduces Copper: Role of Tryptophan Residues☆
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Abbreviations used: PrP, prion protein; β-APP, β-amyloid precursor protein; β-APP135-156, copper binding domain of β-amyloid precursor protein; BC, bathocuproine disulfonic acid disodium salt; PBS, phosphate-buffered saline; PrPC, normal cellular form of prion protein; PrPSc, pathogenic form of prion protein; PrP59–91, copper binding domain of prion protein; Aβ, amyloid-β-peptide
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To whom correspondence and reprint requests should be addressed at the Molecular Neurobiology Unit, Pontifical Catholic University of Chile, P.O. Box 114-D, Santiago, Chile. Fax: 56-2-6862717. E-mail: [email protected].