Biochemical and Biophysical Research Communications
Volume 232, Issue 3, 27 March 1997, Pages 652-655
Regular ArticleA Monoclonal Antibody against Acetylcholinesterase Inhibits the Formation of Amyloid Fibrils Induced by the Enzyme☆
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2019, International Journal of Biological MacromoleculesCitation Excerpt :All these inhibitors interact with PAS of AChE whereas catalytic site-only binding inhibitors such as tacrine and edrophonium were not able to inhibit AChE-induced Aβ aggregation [59]. Also, monoclonal antibody directed towards the PAS of AChE has inhibited the amyloid fibril formation triggered by AChE [58]. Hence, the interaction of AST-SAC with various amino acids present along the active site gorge, in particular with catalytic site and PAS is imperative, since AST-SAC might also inhibit the AChE-induced Aβ aggregation.
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R. D. TerryR. KatzmanK. L. Bick, Eds.
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To whom correspondence should be addressed at Molecular Neurobiology Unit, Catholic University of Chile, P.O. Box 114-D, Santiago, Chile. Fax: 56-2-6862717.
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