Regular ArticleImmunocytochemical Colocalization of Clusterin in Apoptotic Photoreceptor Cells in Retinal Degeneration SlowrdsMutant Mouse Retinas
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Clusterin, other extracellular chaperones, and eye disease
2022, Progress in Retinal and Eye ResearchCitation Excerpt :In the earliest study, differential hybridization screening of a human retinal cDNA library revealed an increase in CLU expression in diseased retina (Jones et al., 1992). Subsequently, increased CLU expression was localized to apoptotic photoreceptors in retinal degenerative disease in humans (Jomary et al., 1993) and also in a mouse model (Jomary et al., 1995; Agarwal et al., 1996). An increase in CLU expression was also seen in light-induced retinal damage in rats (Wong et al., 1994; Jomary, Darrow et al., 1999).
Clusterin in the eye: An old dog with new tricks at the ocular surface
2016, Experimental Eye ResearchCitation Excerpt :Improper photoreceptor development in the vitiligo mutant mouse was accompanied by increased expression of CLU mRNA in the retinal pigment epithelium (Smith et al., 1995). In the retinal degeneration slow mutant mouse, over-expression of CLU co-localized with apoptotic nuclei (Jomary et al., 1995; Agarwal et al., 1996). The pattern of apoptotic nuclear labeling was examined in a rat model of light-induced retinal degeneration.
Nuclear CLU (nclu) and the fate of the cell
2009, Advances in Cancer ResearchCitation Excerpt :In this system, CLU protein and apoptotic nuclei were colocalized using brown and red coloured substrates, respectively. CLU was found colocalized with apoptotic nuclei both in the outer nuclear layer of rds mutant retinas as well as in the small intestine epithelial cells undergoing cell turnover and exfoliation (Agarwal et al., 1996). These results are of high interest for at least two reasons: (i) overexpression of CLU was also observed in other neurodegenerative diseases such as Alzheimer's and Pick's disease; (ii) overexpression of CLU will be found later associated to APC expression in colon cells (Chen et al., 2004), thus accounting for the finding that CLU was localized in small intestine epithelial cells undergoing turnover and exfoliation.
Transplantation of the RPE in AMD
2007, Progress in Retinal and Eye ResearchClusterin/Apolipoprotein J in human aging and cancer
2002, International Journal of Biochemistry and Cell BiologyFlavones from Scutellaria baicalensis Georgi attenuate apoptosis and protein oxidation in neuronal cell lines
2002, Biochimica et Biophysica Acta - General Subjects
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Address for correspondence: Department of Anatomy and Cell Biology, University of North Texas Health Science Center, 3500 Camp Bowie Blvd., Fort Worth, TX 76107-2699. Fax: (817) 735-2610; E-mail: nagarwal@molly. hsc.unt.edu.