Regular ArticlePET- and MRI-Based Assessment of Glucose Utilization, Dopamine Receptor Binding, and Hemodynamic Changes after Lesions to the Caudate-Putamen in Primates
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Longitudinal characterization of cognitive and motor deficits in an excitotoxic lesion model of striatal dysfunction in non-human primates
2019, Neurobiology of DiseaseCitation Excerpt :Such studies have mostly used immunohistochemistry to document changes in neurons and interneurons, by looking at the reduction in markers like DARPP-32, Calbindin, substance P, and TH, and the sparing of other cell types like ChAT and NADPH positive cells (Brownell et al., 1994; Emerich et al., 1997; Emerich et al., 2006; Ferrante et al., 1993; Roitberg et al., 2002; Schumacher et al., 1992). Only a few studies have also combined the post-mortem assessment with an in vivo characterization of the motor impairment (Brownell et al., 1994; Burns et al., 1995; Roitberg et al., 2002; Schumacher et al., 1992), and brain imaging (Hantraye et al., 1992a,b; Lavisse et al., 2015). The severity of the bilateral lesions in the striatum has been documented in rodents (Nash et al., 1991; Pettibone et al., 1978; Tulipan et al., 1986) as leading to a lethal phenotype.
Applications of positron emission tomography in animal models of neurological and neuropsychiatric disorders
2012, Neuroscience and Biobehavioral ReviewsIn vivo imaging of integration and function of striatal grafts in rodent and nonhuman primate animal models
2012, Progress in Brain ResearchCitation Excerpt :This indicates that a continuous decline of nigral dopamine cell function occurs following destruction of their intrinsic striatal target neurons. Other pathways were explored using the general marker of cell metabolism 18F-fluorodeoxyglucose (FDG) which also displays a severe decrease in striatal uptake following excitotoxic lesion (Brownell et al., 1994). Despite the lack of an exact understanding of the cell death mechanisms occurring in HD, major efforts are currently undertaken to find a cure.
Elevated brain 3-hydroxykynurenine and quinolinate levels in Huntington disease mice
2006, Neurobiology of DiseaseCerebral PET imaging and histological evidence of transglutaminase inhibitor cystamine induced neuroprotection in transgenic R6/2 mouse model of Huntington's disease
2005, Journal of the Neurological Sciences