Regular ArticleCharacterization of the Human and Mouse HEY1, HEY2, and HEYL Genes: Cloning, Mapping, and Mutation Screening of a New bHLH Gene Family☆
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2015, Molecular and Cellular EndocrinologyCitation Excerpt :Coactivators such as Mastermind-like (MAML) proteins are recruited forming a complex that induces the expression of downstream target genes. These genes include specific members of the Hes/Hey family of basic helix-loop-helix transcription factors: Hes1, Hes5, Hes7, Hey1, Hey2, and HeyL (Hsieh et al., 1999; Kopan and Ilagan, 2009; Steidl et al., 2000; Wu et al., 2000). Recently, Hilton et al. demonstrated that “upstream” components of the Notch pathway (PS1/PS2 and N1/N2) were critical in regulating osteoblastic differentiation of bone marrow-derived MPCs in mice (Hilton et al., 2008).
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Sequence data from this article have been deposited with the EMBL/GenBank Data Libraries under Accession Nos. (human HEY1) AJ272214, (murine Hey1) AJ243895, (human HEY2) AJ249545, (murine Hey2) AJ271867, (murine HeyL) AJ271868, and (human HEYL) AJ272215.
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To whom correspondence should be addressed at Theodor-Boveri-Institut/Physiologische Chemie I, Biozentrum der Universität Würzburg, Am Hubland, D-97074 Würzburg, Germany. Telephone: (49)-931-888-4159. Fax: (49)-931-888-7038. E-mail: [email protected].