Biochemical and Biophysical Research Communications
Regular ArticleIdentification of the Chemokine Receptor TER1/CCR8 Expressed in Brain-Derived Cells and T Cells as a New Coreceptor for HIV-1 Infection
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Cited by (79)
Biological characterization of ligands targeting the human CC chemokine receptor 8 (CCR8) reveals the biased signaling properties of small molecule agonists
2021, Biochemical PharmacologyCitation Excerpt :It was suggested that CCR8 promotes allergic inflammation and asthma [23–26], although contradictory results have been reported as well [27–29]. CCR8 might also function as HIV co-receptor, facilitating both HIV-1 and HIV-2 infection, at least in vitro [30,31]. CCR8 is also expressed on mouse and human group 2 innate lymphoid cells (ILC2s) [32,33] and on a subgroup of IFN-γ producing intestinal ILCs [34].
Preferential recognition of monomeric CCR5 expressed in cultured cells by the HIV-1 envelope glycoprotein gp120 for the entry of R5 HIV-1
2014, VirologyCitation Excerpt :The 293T and HeLa cells were maintained in Dulbecco's modified Eagle medium (DMEM) (Sigma-Aldrich) supplemented with 10% fetal bovine serum (FBS) (Gibco BRL), 100 U/ml of penicillin and 100 μg/ml of streptomycin. A human CD4-expressing glioma cell line (NP2/CD4) was maintained in Eagle's minimum essential medium (MEM; Gibco BRL) supplemented with 10% FBS, 100 U/ml of penicillin and 100 μg/ml of streptomycin (Jinno et al., 1998). A CXCR4 antagonist AMD3100 (Schols et al., 1997a, 1997b) and a CCR5 antagonist maraviroc (MVC) (Dorr et al., 2005) were supplied by the AIDS Research and Reference Reagent Program, Division of AIDS, National Institute of Allergy and Infectious Diseases.
MOLECULAR DETERMINANTS OF MICROBIAL PATHOGENESIS
2009, Feigin and Cherry's Textbook of Pediatric Infectious Diseases, Sixth EditionChemokines, their Receptors and Significance in Brain Function
2008, NeuroImmune BiologyCitation Excerpt :These results are consistent with a report showing CCL2/MCP-1 immunoreactivity in developing neurons in the cerebellum and pons nuclei of human fetal brain [86]. By reverse transcriptase–polymerase chain reaction (RT–PCR) analysis, CCR1, CCR4, CCR5, and CCR9/10 mRNA was identified in primary culture of hippocampal neurons, with CCR1 also detected in cultured astrocyte populations [87,88] and TER1/CCR8 identified in brain-derived cells [89]. CCR11 mRNA was detected in cultured neonatal mouse astrocytes, while a lower expression level was identified in microglia [88].
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Present address: Institute of Medical Science, Shiroganedai, Minato-ku, Tokyo 108, Japan.
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Corresponding author. Fax: +81-27-220-8006. E-mail:[email protected].